The AFP test involves taking a blood sample. Blood is drawn from a vein (venipuncture), usually from the inside of the elbow or the back of the hand. Usually, there is little pain associated with a blood drawing. When the needle is inserted to draw blood, some people feel moderate discomfort, while others feel only a prick or stinging sensation. There are few risks with this test: Excessive bleeding. Fainting or feeling lightheaded. Hematoma (blood accumulating under the skin). Infection (a slight risk any time the skin is broken). Multiple punctures to locate veins.